Type 2 Diabetes Cases to Swell In Galway as Obesity Rate Rise : Januvia News

Obesity does not always contribute to the development of diabetes, suggest experiments conducted in obese mice. Contrary of the broadly conceived notion, the prevalence of diabetes principally relies on the area where fat is accumulated. During the experiments, mice that were extremely obese and overweight didn't turn diabetic due to the action of two hormones which enabled them to store extra calories in fat tissue in stead of liver or heart muscle.

"What this study illustrates is what we have apprehended clinically awhile," uttered lead researcher Philipp Scherer, a professor of internal medicine and director of the Touchstone Center for Diabetes Research at the University of Texas Southwestern Medical Center at Dallas.

"It basically reveals that individuals who are capable of enhancing the mass of their adipose or fat tissue progressively for the number of calories they consume, fare far better than those who are with a reduced ability to enlarge adipose tissue," Scherer said.

When fat is not stored in the adipose tissue, then it ends up amassing in the liver and muscles. This, in turn, results noteworthy insulin resistance which then may lead to diabetes, Scherer elucidated. During their experiments, Scherer's team illustrated that in genetically-altered mice, the surfeit of adiponectin, a hormone associated with sensitivity to insulin, and a deficit of leptin, a hormone believed to suppresses appetite, enables the mice to amass extra calories in fat tissue rather than liver, muscle or heart tissues, according to the report published in online edition of the Journal of Clinical Investigation on Aug 23.

Scherer further stated that alike mice, the location for fat storage is also determined by genetics in human. "While there are lots of obese people who are not type 2 diabetics, you can even see lean individuals with type 2 diabetes," he added. Type 2 diabetes is the most common form of the diabetes and is often linked to obesity.