Byetta

About 21 million Americans have diabetes. It arises when the body builds resistance to insulin required to break down food, causing blood sugar levels to spike. About 95% adults with diabetes have the Type 2 form and they either don't generate sufficient insulin or their bodies are unsuccessful to use what is produced.

As Januvia has hit the market, it has turned out to be quite a success story; it’s already quite a rage with it being low on costs. Byetta inhibits synthesis of glucagon, slows down gastric emptying and stimulates beta cell neogenesis by prevention in terms of beta cell death. The response of Byetta is visible only in the presence of glucose, which results in a low risk for hypoglycemia.

Byetta is only available in an injection form, which means it has to be injected in the body which results in its downside. DPP – 4 breaks down GLP – 1, which limits GLP- 1 half life to about 90 seconds and is cleared by the kidneys.

Januvia is much more convenient than Byetta as it prevents the breakdown of the body’s own GLP- 1 by blocking DPP-4. Being an oral drug it much more easier to use and its much simpler than an injection.

The effect of both the drugs is quite same which means higher levels of GLP-1 in the body which lowers the chances of hypoglycemia and helps in the reduction of weight.

Januvia is considered much better than Byetta as it requires no refrigeration, only one dose is needed per day and is much cheaper.